Responsive design shouldn’t be just about checking screen width and removing stuff on mobile devices, even though this is what it often amounts to. I also admit to doing this myself. Designing with a mobile first approach is sensible, but we run into problems with the typical wireframes/photoshop/html pixel-perfect workflow.

Stephanie Rieger made this excellent presentation on pragmatic responsive design with lots of good points.

You should check out her other presentations too.